While in South Africa, Ms Rademeyer became proficient in Maitland techniques; she was subsequently selected as chairperson of the manipulative therapy group that developed the manual therapy program at her alma mater. Having achieved considerable success and recognition in her home country, Ms Rademeyer moved to the United States in 1986.

In 1991, Irene was invited by the Florida Spine Institute in Clearwater, FL to open and direct their Physical Therapy Clinic. That same year, she received her Orthopedic Certified Specialist accreditation (which was renewed in 1998).

Irene has continued as Director of Physical Therapy at Florida Spine while finding time to teach post-graduate students in spinal and peripheral joint manual therapy throughout the U.S. Ms. Rademeyer has most recently taught physical therapy students at the University of South Florida as a guest lecturer and has been a member of the panel to select new physical therapy teaching staff at the University.